SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

Huanjiao Jenny Zhou; Zhe Xu; Zongren Wang; Haifeng Zhang; Zhen W. Zhuang; Michael Simons; Wang Min

doi:10.1038/s41467-018-05812-2

Nature Communications (Aug 2018)

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

Huanjiao Jenny Zhou,
Zhe Xu,
Zongren Wang,
Haifeng Zhang,
Zhen W. Zhuang,
Michael Simons,
Wang Min

Affiliations

Huanjiao Jenny Zhou: Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine
Zhe Xu: Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine
Zongren Wang: Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine
Haifeng Zhang: Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine
Zhen W. Zhuang: Section of Cardiology, Department of Internal Medicine, Yale University School of Medicine
Michael Simons: Section of Cardiology, Department of Internal Medicine, Yale University School of Medicine
Wang Min: Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05812-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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