Assembly and functionality of the ribosome with tethered subunits

Nikolay A. Aleksashin; Margus Leppik; Adam J. Hockenberry; Dorota Klepacki; Nora Vázquez-Laslop; Michael C. Jewett; Jaanus Remme; Alexander S. Mankin

doi:10.1038/s41467-019-08892-w

Nature Communications (Feb 2019)

Assembly and functionality of the ribosome with tethered subunits

Nikolay A. Aleksashin,
Margus Leppik,
Adam J. Hockenberry,
Dorota Klepacki,
Nora Vázquez-Laslop,
Michael C. Jewett,
Jaanus Remme,
Alexander S. Mankin

Affiliations

Nikolay A. Aleksashin: Center for Biomolecular Sciences, University of Illinois at Chicago
Margus Leppik: Institute of Molecular and Cell Biology, University of Tartu
Adam J. Hockenberry: Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University
Dorota Klepacki: Center for Biomolecular Sciences, University of Illinois at Chicago
Nora Vázquez-Laslop: Center for Biomolecular Sciences, University of Illinois at Chicago
Michael C. Jewett: Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University
Jaanus Remme: Institute of Molecular and Cell Biology, University of Tartu
Alexander S. Mankin: Center for Biomolecular Sciences, University of Illinois at Chicago

DOI: https://doi.org/10.1038/s41467-019-08892-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal