Progress in storage and clinical application of dental stem cells

Abstract

Derived from the neural crest, dental stem cells (DSCs) are a population of cells with the characteristics of mesenchymal stem⁃ness, which under certain appropriate conditions can differentiate into multiple cells such as os⁃teocytes, chondrocytes, hepatocyte and neuronal ⁃like cells. DSCs are consist of odontogenic stem cells mainly include dental pulp stem cells, periodontal ligament stem cells, stem cells from deciduous teeth, stem cells from apical papilla, as well as dental follicle progenitor cells. DSCs have been widely used in the field of regenerative medicine research and preclinical research, including nervous system diseases, oral diseases, immune diseases, heart and lung diseases, etc. This review will focus on the storage of DSCs and current translational and clinical studies regarding DSCs in tissue regeneration.

Keywords

• Odontogenic
• Stem cells
• Regenerative medicine
• Translational research
• Clinical trials
• Stem cells Banking
• Tissue engineering