ACS Central Science (Jul 2024)
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses
- Melissa Thaler,
- Tim P. Ofman,
- Ken Kok,
- Jurriaan J. A. Heming,
- Elisha Moran,
- Isabelle Pickles,
- Anouk A. Leijs,
- Adrianus M. C. H. van den Nieuwendijk,
- Richard J. B. H. N. van den Berg,
- Gijs Ruijgrok,
- Zachary Armstrong,
- Clarisse Salgado-Benvindo,
- Dennis K. Ninaber,
- Eric J. Snijder,
- Constant A. A. van Boeckel,
- Marta Artola,
- Gideon J. Davies,
- Herman S. Overkleeft,
- Martijn J. van Hemert
Affiliations
- Melissa Thaler
- Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands
- Tim P. Ofman
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Ken Kok
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Jurriaan J. A. Heming
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Elisha Moran
- Department of Chemistry, University of York, York, United Kingdom
- Isabelle Pickles
- Department of Chemistry, University of York, York, United Kingdom
- Anouk A. Leijs
- Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands
- Adrianus M. C. H. van den Nieuwendijk
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Richard J. B. H. N. van den Berg
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Gijs Ruijgrok
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Zachary Armstrong
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Clarisse Salgado-Benvindo
- Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands
- Dennis K. Ninaber
- Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
- Eric J. Snijder
- Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands
- Constant A. A. van Boeckel
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Marta Artola
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Gideon J. Davies
- Department of Chemistry, University of York, York, United Kingdom
- Herman S. Overkleeft
- Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
- Martijn J. van Hemert
- Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands
- DOI
- https://doi.org/10.1021/acscentsci.4c00506
- Journal volume & issue
-
Vol. 10,
no. 8
pp. 1594 – 1608
Abstract
No abstracts available.