Nature Communications (Sep 2017)

GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

  • Lingdi Wang,
  • Iain Scott,
  • Lu Zhu,
  • Kaiyuan Wu,
  • Kim Han,
  • Yong Chen,
  • Marjan Gucek,
  • Michael N. Sack

DOI
https://doi.org/10.1038/s41467-017-00521-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Hepatic gluconeogenesis is tightly regulated at transcriptional level and is essential for survival during prolonged fasting. Here Wang et al. show that the mitochondrial enriched GCN5-like 1 protein controls hepatic glucose production by regulating FoxO1 protein levels via proteasome-dependent degradation and, in turn, gluconeogenic gene expression.