Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
Trivia Frazier,
Andrea Alarcon,
Xiying Wu,
Omair A. Mohiuddin,
Jessica M. Motherwell,
Anders H. Carlsson,
Robert J. Christy,
Judson V. Edwards,
Robert T. Mackin,
Nicolette Prevost,
Elena Gloster,
Qiang Zhang,
Guangdi Wang,
Daniel J. Hayes,
Jeffrey M. Gimble
Affiliations
Trivia Frazier
Obatala Sciences Inc., New Orleans, LA 70148, USA
Andrea Alarcon
Obatala Sciences Inc., New Orleans, LA 70148, USA
Xiying Wu
Obatala Sciences Inc., New Orleans, LA 70148, USA
Omair A. Mohiuddin
Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Science, University of Karachi, Karachi 75270, Pakistan
Jessica M. Motherwell
Walter Reed National Military Medical Center, Bethesda, MD 29814, USA
Anders H. Carlsson
United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA
Robert J. Christy
United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA
Judson V. Edwards
Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA
Robert T. Mackin
Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA
Nicolette Prevost
Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA
Elena Gloster
Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA
Qiang Zhang
Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA
Guangdi Wang
Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA
Daniel J. Hayes
Department of Biomedical Engineering, State College, Pennsylvania State University, Centre County, PA 16802, USA
Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.
