Опухоли женской репродуктивной системы (May 2023)
Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus
- A. S. Tyulyandina,
- E. A. Ulrikh,
- L. A. Kolomiets,
- S. E. Krasilnikov,
- A. G. Kedrova,
- A. A. Rumyantsev,
- G. A. Raskin,
- A. I. Nesterova,
- M. V. Volkonskiy,
- O. N. Churuksaeva,
- A. Yu. Goryainova,
- V. V. Zhavoronkova,
- V. N. Dmitriev,
- S. T. Nazranova,
- A. V. Shkradyuk,
- K. S. Volkova,
- A. I. Arutyunova,
- S. N. Kunitskaya,
- L. V. Stepura,
- T. G. Zolotoreva,
- E. B. Shakhnovich,
- E. V. Ponomareva,
- M. A. Strokova,
- A. S. Danilova,
- E. S. Martynova
Affiliations
- A. S. Tyulyandina
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
- E. A. Ulrikh
- N.N. Petrov National Medical Research Institute of Oncology, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
- L. A. Kolomiets
- Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
- S. E. Krasilnikov
- Institute of Oncology and Neurosurgery, E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia
- A. G. Kedrova
- Department of Oncology, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation; Department of Obstetrics and Gynecology, Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation
- A. A. Rumyantsev
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- G. A. Raskin
- Saint Petersburg State University; Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems
- A. I. Nesterova
- Republican Clinical Oncology Dispensary, Ministry of Health of the Republic of Tatarstan; Kazan Federal University
- M. V. Volkonskiy
- Moscow City Oncology Hospital No. 62, Moscow Healthcare Department
- O. N. Churuksaeva
- Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
- A. Yu. Goryainova
- Clinical Oncology Dispensary No. 1; Kuban State Medical University
- V. V. Zhavoronkova
- Volgograd Regional Clinical Oncology Dispensary; Volgograd State Medical University, Ministry of Health of Russia
- V. N. Dmitriev
- Belgorod National Research University; Belgorod Oncology Dispensary
- S. T. Nazranova
- Oncology Dispensary, Ministry of Health of Kabardino-Balkar Republic
- A. V. Shkradyuk
- V.M. Efetov Crimean Republican Oncology Clinical Dispensary
- K. S. Volkova
- Samara Regional Clinical Oncology Dispensary
- A. I. Arutyunova
- Pyatigorsk Regional Oncology Dispensary
- S. N. Kunitskaya
- V.M. Efetov Crimean Republican Oncology Clinical Dispensary
- L. V. Stepura
- Oncology Dispensary in Shakhty
- T. G. Zolotoreva
- Samara Regional Clinical Oncology Dispensary
- E. B. Shakhnovich
- Korolev City Hospital
- E. V. Ponomareva
- V.M. Efetov Crimean Republican Oncology Clinical Dispensary
- M. A. Strokova
- V.M. Efetov Crimean Republican Oncology Clinical Dispensary
- A. S. Danilova
- Moscow City Oncology Hospital No. 62, Moscow Healthcare Department
- E. S. Martynova
- A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
- DOI
- https://doi.org/10.17650/1994-4098-2022-18-4-138-146
- Journal volume & issue
-
Vol. 18,
no. 4
pp. 138 – 146
Abstract
Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI.
Keywords
- deficient dna mismatch repair
- microsatellite instability
- immunotherapy
- endometrial cancer
- uterine cancer
- pembrolizumab
- lenvatinib
