A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

Annamaria Sgromo; Tobias Raisch; Praveen Bawankar; Dipankar Bhandari; Ying Chen; Duygu Kuzuoğlu-Öztürk; Oliver Weichenrieder; Elisa Izaurralde

doi:10.1038/ncomms14307

Nature Communications (Feb 2017)

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

Annamaria Sgromo,
Tobias Raisch,
Praveen Bawankar,
Dipankar Bhandari,
Ying Chen,
Duygu Kuzuoğlu-Öztürk,
Oliver Weichenrieder,
Elisa Izaurralde

Affiliations

Annamaria Sgromo: Department of Biochemistry, Max Planck Institute for Developmental Biology
Tobias Raisch: Department of Biochemistry, Max Planck Institute for Developmental Biology
Praveen Bawankar: Department of Biochemistry, Max Planck Institute for Developmental Biology
Dipankar Bhandari: Department of Biochemistry, Max Planck Institute for Developmental Biology
Ying Chen: Department of Biochemistry, Max Planck Institute for Developmental Biology
Duygu Kuzuoğlu-Öztürk: Department of Biochemistry, Max Planck Institute for Developmental Biology
Oliver Weichenrieder: Department of Biochemistry, Max Planck Institute for Developmental Biology
Elisa Izaurralde: Department of Biochemistry, Max Planck Institute for Developmental Biology

DOI: https://doi.org/10.1038/ncomms14307
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal