Frontiers in Human Neuroscience (Feb 2025)
Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
- Alfonso Enrique Martinez-Nunez,
- Christopher J. Rozell,
- Simon Little,
- Huiling Tan,
- Stephen L. Schmidt,
- Warren M. Grill,
- Warren M. Grill,
- Miroslav Pajic,
- Dennis A. Turner,
- Dennis A. Turner,
- Dennis A. Turner,
- Coralie de Hemptinne,
- Andre Machado,
- Andre Machado,
- Nicholas D. Schiff,
- Abbey S. Holt-Becker,
- Robert S. Raike,
- Mahsa Malekmohammadi,
- Mahsa Malekmohammadi,
- Yagna J. Pathak,
- Lyndahl Himes,
- David Greene,
- Lothar Krinke,
- Lothar Krinke,
- Mattia Arlotti,
- Lorenzo Rossi,
- Jacob Robinson,
- Jacob Robinson,
- Bahne H. Bahners,
- Bahne H. Bahners,
- Bahne H. Bahners,
- Vladimir Litvak,
- Luka Milosevic,
- Luka Milosevic,
- Saadi Ghatan,
- Saadi Ghatan,
- Frederic L. W. V. J. Schaper,
- Michael D. Fox,
- Nicholas M. Gregg,
- Cynthia Kubu,
- James J. Jordano,
- James J. Jordano,
- James J. Jordano,
- Nicola G. Cascella,
- YoungHoon Nho,
- Casey H. Halpern,
- Casey H. Halpern,
- Helen S. Mayberg,
- Helen S. Mayberg,
- Helen S. Mayberg,
- Ki Sueng Choi,
- Ki Sueng Choi,
- Haneul Song,
- Jungho Cha,
- Sankaraleengam Alagapan,
- Nico U. F. Dosenbach,
- Nico U. F. Dosenbach,
- Nico U. F. Dosenbach,
- Nico U. F. Dosenbach,
- Nico U. F. Dosenbach,
- Nico U. F. Dosenbach,
- Evan M. Gordon,
- Jianxun Ren,
- Hesheng Liu,
- Hesheng Liu,
- Lorraine V. Kalia,
- Lorraine V. Kalia,
- Sarah-Anna Hescham,
- Sarah-Anna Hescham,
- Sarah-Anna Hescham,
- Dorian M. Kusyk,
- Adolfo Ramirez-Zamora,
- Kelly D. Foote,
- Michael S. Okun,
- Joshua K. Wong
Affiliations
- Alfonso Enrique Martinez-Nunez
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Christopher J. Rozell
- School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States
- Simon Little
- Movement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, United States
- Huiling Tan
- Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
- Stephen L. Schmidt
- Departments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States
- Warren M. Grill
- Departments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States
- Warren M. Grill
- Department of Neurobiology, Duke University Medical Center, Durham, NC, United States
- Miroslav Pajic
- Departments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States
- Dennis A. Turner
- Departments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States
- Dennis A. Turner
- Department of Neurobiology, Duke University Medical Center, Durham, NC, United States
- Dennis A. Turner
- Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States
- Coralie de Hemptinne
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Andre Machado
- Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States
- Andre Machado
- Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States
- Nicholas D. Schiff
- 0Weill Cornell Medical College, Feil Family Brain and Mind Research Institute, New York, NY, United States
- Abbey S. Holt-Becker
- 1Restorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States
- Robert S. Raike
- 1Restorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States
- Mahsa Malekmohammadi
- 2Department of Neurosurgery, University of California, Los Angeles, CA, United States
- Mahsa Malekmohammadi
- 3Boston Scientific Neuromodulation, Valencia, CA, United States
- Yagna J. Pathak
- 4Neuromodulation Division, Abbott, Plano, TX, United States
- Lyndahl Himes
- 4Neuromodulation Division, Abbott, Plano, TX, United States
- David Greene
- 5NeuroPace, Inc., Mountain View, CA, United States
- Lothar Krinke
- 6Newronika SpA, Milan, Italy
- Lothar Krinke
- 7West Virginia University, Morgantown, WV, United States
- Mattia Arlotti
- 6Newronika SpA, Milan, Italy
- Lorenzo Rossi
- 6Newronika SpA, Milan, Italy
- Jacob Robinson
- 8Department of Bioengineering, Rice University, Houston, TX, United States
- Jacob Robinson
- 9Department of Electrical and Computer Engineering, Rice University, Houston, TX, United States
- Bahne H. Bahners
- 0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States
- Bahne H. Bahners
- 1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- Bahne H. Bahners
- 2Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- Vladimir Litvak
- 3Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom
- Luka Milosevic
- 4Clinical and Computational Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON, Canada
- Luka Milosevic
- 5Faculty of Medicine, Institute for Neuromodulation and Neurotechnology, University Hospital Tübingen (UKT), University Tübingen, Tübingen, Germany
- Saadi Ghatan
- 6Department of Neurosurgery, Mount Sinai Medical Center, New York, NY, United States
- Saadi Ghatan
- 7Department of Neurosurgery, Maria Fareri Children's Hospital, Westchester Medical Center, Valhalla, NY, United States
- Frederic L. W. V. J. Schaper
- 0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States
- Michael D. Fox
- 0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States
- Nicholas M. Gregg
- 8Department of Neurology, Mayo Clinic, Rochester, MN, United States
- Cynthia Kubu
- Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States
- James J. Jordano
- 9Department of Neurology, Georgetown University Medical Center, Washington, DC, United States
- James J. Jordano
- 0Department of Biochemistry, Georgetown University Medical Center, Washington, DC, United States
- James J. Jordano
- 1Neuroethics Studies Program, Georgetown University Medical Center, Washington, DC, United States
- Nicola G. Cascella
- 2Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- YoungHoon Nho
- 3Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States
- Casey H. Halpern
- 3Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States
- Casey H. Halpern
- 4Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States
- Helen S. Mayberg
- 5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Helen S. Mayberg
- 6Department of Radiology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Helen S. Mayberg
- 7Department of Neurology and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Ki Sueng Choi
- 5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Ki Sueng Choi
- 6Department of Radiology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Haneul Song
- 5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Jungho Cha
- 5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Sankaraleengam Alagapan
- School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States
- Nico U. F. Dosenbach
- 8Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States
- Nico U. F. Dosenbach
- 9Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
- Nico U. F. Dosenbach
- 0Department of Psychological & Brain Sciences, Washington University, St. Louis, MO, United States
- Nico U. F. Dosenbach
- 1Department of Biomedical Engineering, Washington University, St. Louis, MO, United States
- Nico U. F. Dosenbach
- 2Program in Occupational Therapy, Washington University, St. Louis, MO, United States
- Nico U. F. Dosenbach
- 3Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States
- Evan M. Gordon
- 4Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
- Jianxun Ren
- 5Changping Laboratory, Beijing, China
- Hesheng Liu
- 5Changping Laboratory, Beijing, China
- Hesheng Liu
- 6Biomedical Pioneering Innovation Center, Peking University, Beijing, China
- Lorraine V. Kalia
- 7Edmond J Safra Program in Parkinson's Disease, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada
- Lorraine V. Kalia
- 8Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada
- Sarah-Anna Hescham
- 9School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands
- Sarah-Anna Hescham
- 0Department of Neurosurgery, Maastricht University Medical Center, Maastricht, Netherlands
- Sarah-Anna Hescham
- 1Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany
- Dorian M. Kusyk
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Adolfo Ramirez-Zamora
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Kelly D. Foote
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Michael S. Okun
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Joshua K. Wong
- Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- DOI
- https://doi.org/10.3389/fnhum.2025.1544994
- Journal volume & issue
-
Vol. 19
Abstract
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson’s disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.
Keywords
