Solubility Behaviour of Aripiprazole in Different Solvent Systems

Abstract

Background This current research work discusses the Aripiprazolersquos solubility behaviour in individual solvents and solvent blends to offer some theoretical foundation for the formulation scientists regarding solute solvent interactions. AimsObjectives Solubility behaviour of Aripiprazole a poorly soluble drug was studied using biocompatible solvents like polyethylene glycol 400 PEG-400 ethanol propylene glycol PG glycerin and pharmaceutically utilized solvents such as dioxane hexane and ethyl acetate in pure form and their blends. Methods Saturation solubility of Aripiprazole was studied by placing the drug in excess solvent systems using cryostatic constant temperature shaker bath for 72 hours. The solutions after equilibrium were analyzed spectrophotometrically.Results Physico-chemical characteristics of the solvents and Aripiprazole such as intermolecular interactions hydrogen bonding hydrophobic interactions and certain specific solute solvent interactions were noticed for enhanced aqueous solubility AS of Aripiprazole.Conclusion Less polar solvents were shown to significantly increase AS highlighting the hydrophobic interaction strategy. The order of cosolvents increasing AS of Aripiprazole was PEG 400 gt dioxane gt ethylacetate gt ethanol gt PG gt glycerin gt hexane. Based on the data specific combinations were shown to be helpful in the production of Aripiprazole injections and liquid orals. As a result the study produced a significant dataset for comparing how different cosolvents affected the solubility of Aripiprazole and how Aripiprazole formulations were designed.