Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

Abstract

Porcine epidemic diarrhoea virus (PEDV) infection causes watery diarrhoea, vomiting, anorexia, and weight loss, especially among neonatal piglets, inflicting on them morbidity and mortality potentially reaching 90%–100%. Despite it being known that certain mammalian cell phases are arrested by PEDV, the mechanisms have not been elucidated, and PEDV pathogenesis is poorly understood. This study determined the effect of an epidemic PEDV strain on cell cycle progression.

Keywords

• porcine epidemic diarrhoea virus
• cell cycle
• virus proliferation
• dna damage
• signalling pathways