Nature Communications (Jul 2018)
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
- Seyedeh M. Zekavat,
- Sanni Ruotsalainen,
- Robert E. Handsaker,
- Maris Alver,
- Jonathan Bloom,
- Timothy Poterba,
- Cotton Seed,
- Jason Ernst,
- Mark Chaffin,
- Jesse Engreitz,
- Gina M. Peloso,
- Ani Manichaikul,
- Chaojie Yang,
- Kathleen A. Ryan,
- Mao Fu,
- W. Craig Johnson,
- Michael Tsai,
- Matthew Budoff,
- Ramachandran S. Vasan,
- L. Adrienne Cupples,
- Jerome I. Rotter,
- Stephen S. Rich,
- Wendy Post,
- Braxton D. Mitchell,
- Adolfo Correa,
- Andres Metspalu,
- James G. Wilson,
- Veikko Salomaa,
- Manolis Kellis,
- Mark J. Daly,
- Benjamin M. Neale,
- Steven McCarroll,
- Ida Surakka,
- Tonu Esko,
- Andrea Ganna,
- Samuli Ripatti,
- Sekar Kathiresan,
- Pradeep Natarajan,
- NHLBI TOPMed Lipids Working Group
Affiliations
- Seyedeh M. Zekavat
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Sanni Ruotsalainen
- Institute for Molecular Medicine, University of Helsinki
- Robert E. Handsaker
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Maris Alver
- Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu
- Jonathan Bloom
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Timothy Poterba
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Cotton Seed
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Jason Ernst
- Department of Biological Chemistry, University of California, Los Angeles
- Mark Chaffin
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Jesse Engreitz
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Gina M. Peloso
- Department of Biostatistics, Boston University School of Public Health
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia
- Chaojie Yang
- Center for Public Health Genomics, University of Virginia
- Kathleen A. Ryan
- Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of Medicine
- Mao Fu
- Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of Medicine
- W. Craig Johnson
- Department of Biostatistics, School of Public Health and Community Medicine, University of Washington
- Michael Tsai
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Matthew Budoff
- Division of Cardiology, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute
- Ramachandran S. Vasan
- NHLBI Framingham Heart Study
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Jerome I. Rotter
- Departments of Pediatrics and Medicine, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Wendy Post
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Braxton D. Mitchell
- Department of Medicine, University of Maryland School of Medicine
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- Andres Metspalu
- Estonian Genome Center
- James G. Wilson
- Department of Medicine, University of Mississippi Medical Center
- Veikko Salomaa
- National Institute for Health and Welfare
- Manolis Kellis
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Mark J. Daly
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Benjamin M. Neale
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Steven McCarroll
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Ida Surakka
- Institute for Molecular Medicine, University of Helsinki
- Tonu Esko
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Andrea Ganna
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Samuli Ripatti
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Sekar Kathiresan
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Pradeep Natarajan
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- NHLBI TOPMed Lipids Working Group
- DOI
- https://doi.org/10.1038/s41467-018-04668-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels.
