Computational and Mathematical Biophysics (Jul 2024)

Analytic solution of a fractional-order hepatitis model using Laplace Adomian decomposition method and optimal control analysis

  • Aguegboh Nnaemeka S.,
  • Roy Kiogora Phineas,
  • Felix Mutua,
  • Okongo Walter,
  • Diallo Boubacar

DOI
https://doi.org/10.1515/cmb-2023-0114
Journal volume & issue
Vol. 12, no. 1
pp. 26 – 40

Abstract

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Infectious illnesses like hepatitis place a heavy cost on global health, and precise mathematical models must be created in order to understand and manage them. The Adomian decomposition method (ADM) and an optimal control strategy are utilized to solve a fractional-order hepatitis model in this research. By adding fractional derivatives to account for memory effects and non-integer order dynamics, the fractional-order model expands the conventional compartmental model to take into account the complexity of hepatitis dynamics. The fractional-order hepatitis model is resolved using the ADM, a powerful and effective analytical approach. This approach offers a series solution that converges quickly, enabling the model’s precise analytical solution to be derived. To identify crucial criteria and enhance control mechanisms for the management of hepatitis, an optimal solution strategy is also introduced. The optimization procedure tries to lessen the disease’s spread and its negative effects on public health. We can find the best interventions, immunization schedules, and treatment regimens to effectively reduce the hepatitis pandemic by integrating the ADM solution with an optimization framework. The findings of this study show that the suggested method may be used to solve the fractional-order hepatitis model and optimize control measures. The analytical solution produced by ADM offers important insights into the underlying dynamics of hepatitis transmission, and the optimization process produces suggestions that public health professionals and politicians may put into practice. In the end, this research presents a promising direction for improving disease control efforts in a fractional-order context and contributes to a deeper understanding of hepatitis epidemiology. The importance of this method is that it gives solutions that coincide with that obtained using the numerical approach.

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