Infection and Drug Resistance (Mar 2023)
Analysis of Pathogenic Bacteria and Drug Resistance Among Girls with Bacterial Vaginitis
Abstract
Miao Zhang, Jing Liu, Yu-Chen Pan, Hui-Li Liu, Jing Shu, Xiao-Ming Wu, Yang Yang Department of Pediatric Gynecology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, ChinaCorrespondence: Jing Liu, Department of Pediatric Gynecology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, People’s Republic of China, Tel +86 010 59616889, Email [email protected]: The aim of this study was to analyze the prevalence of vaginal flora and drug resistance in bacterial vaginitis among girls.Methods: A total of 3099 girls (0– 10 years old) with vaginitis who visited the Beijing Children’s Hospital from January 2020 to December 2021 were included in the present study. The clinical data, results of bacterial culture of vaginal secretions, and drug sensitivity reports of the subjects were collected and analyzed.Results: Of the 3099 girls with vaginitis, 399 girls had a positive bacterial culture of vaginal secretions. Nineteen types of bacteria were cultured from the vaginal secretions of these 399 girls, with a total of 419 strains. The top three infective bacteria were Haemophilus influenzae (127 strains, 30.31%), Staphylococcus aureus (66 strains, 15.75%), and Streptococcus agalactiae (32 strains, 7.64%). Additionally, 20 girls were simultaneously infected with two types of bacteria. Staphylococcus aureus, Group G Streptococcus, Haemophilus parainfluenzae, and Pseudomonas aeruginosa more frequently occurred in mixed infections. The number and bacterial detection rate among school-age girls were higher than those of preschool-age girls. We found seasonal variation in infection rates, and vaginitis among girls was higher in summer. Recurrence of vaginitis in girls was not related to the type of pathogenic bacteria in the infection. Drug sensitivity analyses showed that the resistance rates of clindamycin and erythromycin were generally high, 70– 100%. After the coronavirus disease 2019 outbreak, the resistance rates of some antibiotics had decreased to varying degrees.Conclusion: Improving the understanding of vaginal flora and drug resistance in girls with vaginitis will facilitate the selection of highly effective and sensitive antibacterial drugs and reduce the production of drug-resistant strains.Keywords: drug sensitivity analysis, girls, pathogenic bacteria, vaginitis
