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Détection luminale des micelles lipidiques

Oléagineux, Corps gras, Lipides. 2012;19(4):196-199 DOI 10.1051/ocl.2012.0448

 

Journal Homepage

Journal Title: Oléagineux, Corps gras, Lipides

ISSN: 1258-8210 (Print); 1950-697X (Online)

Publisher: John Libbey Eurotext

Society/Institution: ETIG

LCC Subject Category: Technology: Chemical technology: Oils, fats, and waxes

Country of publisher: France

Language of fulltext: French, English

Full-text formats available: PDF, HTML

 

AUTHORS


Beaslas Olivier

Cueille Carine

Delers François

Chateau Danielle

Chambaz Jean

Rousset Monique

Carrière Véronique

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks

 

Abstract | Full Text

Post-prandial hypertriglyceridemia is a risk factor for metabolic diseases. The intestine, through its role in alimentary lipid absorption, participates in the secretion of lipoprotein rich-triglycerides (TRL) and contributes to the increase in plasma triglyceride levels during the postprandial state. Understanding the molecular mechanisms involved in the secretion of intestinal TRL would allow the identification of new drug targets for treatment of metabolic diseases. The sensing of lipids by intestinal cells represents a promising mechanism allowing the modulation of TRL secretion. While many studies show the importance of enteroendocrine cells in the detection of alimentary lipids, several evidence suggest also the implication of enterocytes, the absorptive intestinal cells, in this process. Recent experimental results on the role of the scavenger receptor SR-BI in the detection of dietary lipids, supplied in their physiological form of postprandial lipid micelles, are reviewed.