Colonization resistance of the intestinal mucosa in experimental yersiniosis

Abstract

The effect of prebiotic Stimbifid and low-molecular exometabolites in the supernatant fluid of native cultures of prebiotic bifidobacteria and lactobacilli possessing prebiotic effect on the prevention of intestinal yersiniosis in the conventional white mice was investigated. Experimental animals were infected orally with intestinal yersiniosis pathogen Yersinia enterocolitica, isolated from patient with manifested form of infection. Prebiotic Stimbifid, supernatant fluids of native cultures of Bifidobacteria and Lactobacteria, which form the basis of probiotics Bifidumbacterin and Lactobacterin, when administered orally to infected animals completely stopped the development of intestinal yersiniosis and prevented the dysbiotic changes in the intestinal microflora.

Keywords

• кишечный иерсиниоз
• белые мыши
• дисбактериоз
• пребиотик
• пробиотик
• экзометаболиты