Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin

Sanliang Li; Qiaoyu Chen; Zhan-Ming Zhang; Junliang Zhang

Green Synthesis and Catalysis (Nov 2021)

Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin

Sanliang Li,
Qiaoyu Chen,
Zhan-Ming Zhang,
Junliang Zhang

Affiliations

Sanliang Li: Department of Chemistry, Fudan University, Shanghai 200438, China
Qiaoyu Chen: Department of Chemistry, Fudan University, Shanghai 200438, China
Zhan-Ming Zhang: Corresponding authors.; Department of Chemistry, Fudan University, Shanghai 200438, China
Junliang Zhang: Corresponding authors.; Department of Chemistry, Fudan University, Shanghai 200438, China

Journal volume & issue: Vol. 2, no. 4
pp. 374 – 376

Abstract

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A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligand and diverse transformations.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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