S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions

Qiwei Jiang; Xiaomei Zhang; Xiaoming Dai; Shiyao Han; Xueji Wu; Lei Wang; Wenyi Wei; Ning Zhang; Wei Xie; Jianping Guo

doi:10.1038/s41467-022-28910-8

Nature Communications (Mar 2022)

S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions

Qiwei Jiang,
Xiaomei Zhang,
Xiaoming Dai,
Shiyao Han,
Xueji Wu,
Lei Wang,
Wenyi Wei,
Ning Zhang,
Wei Xie,
Jianping Guo

Affiliations

Qiwei Jiang: Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University
Xiaomei Zhang: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University
Xiaoming Dai: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Shiyao Han: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University
Xueji Wu: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University
Lei Wang: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University
Wenyi Wei: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Ning Zhang: Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University
Wei Xie: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University
Jianping Guo: Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-022-28910-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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The direct upstream regulation of PDK1 is not fully understood. Here the authors demonstrate that S6K1 directly phosphorylates PDK1 to inhibit AKT kinase activity and its ability to drive tumourigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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