In vitro antioxidant and cytotoxic activities of essential oil of Feronia elephantum Correa

Abstract

Objective: To analyse the chemical composition and evaluation of antioxidant, cytotoxic and DNA fragmentation activities of essential oil of Feronia elephantum Correa. Methods: Chemical composition analysis of hydrodistilled essential oil was determined by gas chromatography-mass spectrometry and in vitro antioxidant activity of oil was determined by DPPH free radical, hydroxyly radical scavenging, metal chelating and prevention of deoxyribose degradation. Cytotoxicity and DNA fragmentation activities against breast cancer cells (MCF-7) were also analyzed. Results: Gas chromatography-mass spectrometry analysis revealed the presence of 24 compounds with caryophyllene oxide (62.29%) as major compound. A considerable antioxidant, cyotoxic and DNA fragmentation activities of oils was observed. Conclusions: The result of this study clearly indicates oil could be useful for food preservation and preparation.

Keywords

• Feronia elephantum
• Essential oil
• Antioxidant
• Cytotoxicity
• DNA fragmentation