Nature Communications (Jan 2020)

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

  • Evi Goulielmaki,
  • Anna Ioannidou,
  • Maria Tsekrekou,
  • Kalliopi Stratigi,
  • Ioanna K. Poutakidou,
  • Katerina Gkirtzimanaki,
  • Michalis Aivaliotis,
  • Konstantinos Evangelou,
  • Pantelis Topalis,
  • Janine Altmüller,
  • Vassilis G. Gorgoulis,
  • Georgia Chatzinikolaou,
  • George A. Garinis

DOI
https://doi.org/10.1038/s41467-019-13894-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose uptake in recipient cells, leading to increased inflammation.