Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection

Chia-Jung Kuo; Cheng-Han Lee; Ming-Ling Chang; Cheng-Yu Lin; Wey-Ran Lin; Ming-Yao Su; Cheng-Hsun Chiu; Chi-Nan Tseng; Yu-Shan Wu; Cheng-Tang Chiu; Chih-Ho Lai

Journal of Microbiology, Immunology and Infection (Dec 2021)

Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection

Chia-Jung Kuo,
Cheng-Han Lee,
Ming-Ling Chang,
Cheng-Yu Lin,
Wey-Ran Lin,
Ming-Yao Su,
Cheng-Hsun Chiu,
Chi-Nan Tseng,
Yu-Shan Wu,
Cheng-Tang Chiu,
Chih-Ho Lai

Affiliations

Chia-Jung Kuo: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Cheng-Han Lee: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Ming-Ling Chang: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan
Cheng-Yu Lin: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Wey-Ran Lin: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan
Ming-Yao Su: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Gastroenterology and Hepatology, New Taipei Municipal Tucheng Hospital, New Taipei, Taiwan
Cheng-Hsun Chiu: College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Chi-Nan Tseng: Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Yu-Shan Wu: Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Cheng-Tang Chiu: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Corresponding author. Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan. Fax: +886 3 3272236.
Chih-Ho Lai: Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan; Department of Nursing, Asia University, Taichung, Taiwan; Department of Medical Research, School of Medicine, China Medical University and Hospital, Taichung, Taiwan; Corresponding author. Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Fax: +886 3 2118700.

Journal volume & issue: Vol. 54, no. 6
pp. 1184 – 1187

Abstract

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This study investigated the antimicrobial resistance of isolates from patients with refractory Helicobacter pylori. The resistance rate was 34.1% for amoxicillin, 92.7% for clarithromycin, 65.9% for metronidazole, 85.4% for levofloxacin, and 29.3% for rifabutin. Dual resistance to both clarithromycin and levofloxacin was found in 73.2%. The antimicrobial resistance rate of refractory H. pylori was extremely high, which had become a major consideration in therapeutic challenge.

Published in Journal of Microbiology, Immunology and Infection

ISSN: 1684-1182 (Print)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Science: Microbiology
Website: https://www.sciencedirect.com/journal/journal-of-microbiology-immunology-and-infection

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