DISSEMINATED INTRAVASCULAR COAGULATION IN CHILDREN. DIAGNOSTICS AND TREATMENT

Abstract

The article focuses on modern approaches to pathophysiology, diagnostics and treatment of disseminated intravascular coagulation. Consumptive coagulopathy is a serious complication and associated with significantly increased mortality in children. The causes of developing disseminated intravascular coagulation (DIC) may be a systemic inflammatory response and/or an entry of procoagulant material into bloodstream. Chronic DIC may run with no symptoms whilst the acute DIC may be accompanied with bleeding, thrombosis, and multiorgan failure. The laboratory diagnostics should be serial and determine the combination of blood coagulation indicators. DIC is a secondary clinical manifestation of the core pathology, hence the key objective of an integrated therapy is to treat the core disease. Key words: Disseminated Intravascular Coagulation, causes, pathogenesis, diagnostics, treatment, children. (Pediatric Pharmacology. – 2010; 7(6):27-31)