Nature Communications (Sep 2018)

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

  • Arin Marchesi,
  • Xiaolong Gao,
  • Ricardo Adaixo,
  • Jan Rheinberger,
  • Henning Stahlberg,
  • Crina Nimigean,
  • Simon Scheuring

DOI
https://doi.org/10.1038/s41467-018-06414-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction, but conformational changes associated with gating remained unknown. Here authors use high-speed atomic force microscopy to visualize SthK channels dynamics in response to cyclic nucleotides.