In vitro mass reduction of calcium oxalate urinary calculi by some medicinal plants

Abstract

Abstract Background Calcium oxalate is the most frequent urinary stone component; it exists in three different crystalline forms. In this case, the most common is the calcium oxalate monohydrate (whewellite). However, Morocco is one of the countries that has used the traditional medicine based on natural plants to treat many diseases including urolithiasis. In this respect, the most medicinal plants used for this purpose are Herniaria hirsuta L., Opuntia ficus-indica flowers, Zea mays styles and Ammi visnaga L. seeds. The purpose of this work is to study experimentally the effectiveness of each plant on the dissolution of whewellite stones. Methods In 1 L boiled saline solution (9 g/L of NaCl), 5 g of plant extract powder has been introduced. Thereafter, the mixture was left soaked for 15 min and then filtered. Further, a specific installation that resembles the urinary circuit has been conducted in the laboratory. As a starting step, three whewellite stones are placed in contact with extract solutions for 8 weeks. Two other solutions have been used to correct the loss mass: the first one is a solution of potassium citrate of 3 mmol/L served as a positive control, and the second one is a solution of NaCl of 9 g/L without extract used as a reference point. Results After 8 weeks, the loss mass is about 54.88 ± 1.32% with Z. mays styles, 49.86 ± 1.69% with H. hirsuta L., 47.10 ± 1019% with A. visnaga L. and 44.97 ± 1.76% with flowers O. ficus-indica, while the loss of mass in the presence of witnesses solutions is 21.95 ± 0.76% for potassium citrate (C Pot) and 21.05 ± 1.07% in the case of saline solutions. Conclusion Our experiments show the effectiveness of the extracts of four plants specially for Z. mays styles. These extracts can be effective remedies in the oxalocalcic stones’ dissolution.

Keywords

• Nephrolithiasis
• Medicinal plants
• Urinary stones
• Potassium citrate
• Dissolution rate