Nature Communications (Apr 2019)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
- Suman De,
- David C. Wirthensohn,
- Patrick Flagmeier,
- Craig Hughes,
- Francesco A. Aprile,
- Francesco S. Ruggeri,
- Daniel R. Whiten,
- Derya Emin,
- Zengjie Xia,
- Juan A. Varela,
- Pietro Sormanni,
- Franziska Kundel,
- Tuomas P. J. Knowles,
- Christopher M. Dobson,
- Clare Bryant,
- Michele Vendruscolo,
- David Klenerman
Affiliations
- Suman De
- Department of Chemistry, University of Cambridge
- David C. Wirthensohn
- Department of Chemistry, University of Cambridge
- Patrick Flagmeier
- Department of Chemistry, University of Cambridge
- Craig Hughes
- Department of Chemistry, University of Cambridge
- Francesco A. Aprile
- Department of Chemistry, University of Cambridge
- Francesco S. Ruggeri
- Department of Chemistry, University of Cambridge
- Daniel R. Whiten
- Department of Chemistry, University of Cambridge
- Derya Emin
- Department of Chemistry, University of Cambridge
- Zengjie Xia
- Department of Chemistry, University of Cambridge
- Juan A. Varela
- Department of Chemistry, University of Cambridge
- Pietro Sormanni
- Department of Chemistry, University of Cambridge
- Franziska Kundel
- Department of Chemistry, University of Cambridge
- Tuomas P. J. Knowles
- Department of Chemistry, University of Cambridge
- Christopher M. Dobson
- Department of Chemistry, University of Cambridge
- Clare Bryant
- Department of Veterinary Medicine, University of Cambridge
- Michele Vendruscolo
- Department of Chemistry, University of Cambridge
- David Klenerman
- Department of Chemistry, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-019-09477-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease. This study shows how different types of Aβ42 aggregates are associated with distinct mechanisms of toxicity
