Nature Communications (Jan 2018)

KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

  • Mel Campbell,
  • Tadashi Watanabe,
  • Kazushi Nakano,
  • Ryan R. Davis,
  • Yuanzhi Lyu,
  • Clifford G. Tepper,
  • Blythe Durbin-Johnson,
  • Masahiro Fujimuro,
  • Yoshihiro Izumiya

DOI
https://doi.org/10.1038/s41467-017-02089-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.