Development of Advanced Macrosphelides: Potent Anticancer Agents

Abstract

Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.

Keywords

• macrosphelides
• medicinal chemistry
• analogs