The aim of this study was to determine the efficacy of combination therapy based on acceptance, commitment and hope in improving quality of life in patients with cancer in Yasuj. The research method is a semi-experimental design with pre-test and post-test design with two experimental and control groups. The statistical population of this study included 100 cancer patients who were admitted to Yasuj Shahid Beheshti Hospitals in the 3rd month of 1396 and the first two months of 2018and have clinical records. In a simple random sampling, 30 patients between the ages of 19 and 55 years were selected for chemotherapy in the center and divided into two groups of 15 subjects. In this study, there was no limited type of cancer, and the criteria for entering the study were as follows: being alert, aged 19 to 55 years, definite diagnosis of cancer with the approval of a specialist physician, at least once, treatment with chemotherapy drugs, and for data collection and analysis. Life expectancy inventory and covariance analysis were used. The findings of the study showed that combination therapy based on acceptance, commitment, and hope of health in improving the quality of life in Yasuj is significant level for confirming the hypothesis of P <0.5.