Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Apr 2023)
Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research
- Jack Carson Taylor,
- Hilary W. Heuer,
- Annie L. Clark,
- Amy B. Wise,
- Masood Manoochehri,
- Leah Forsberg,
- Carly Mester,
- Meghana Rao,
- Daniell Brushaber,
- Joel Kramer,
- Ariane E. Welch,
- John Kornak,
- Walter Kremers,
- Brian Appleby,
- Bradford C. Dickerson,
- Kimiko Domoto‐Reilly,
- Julie A. Fields,
- Nupur Ghoshal,
- Neill Graff‐Radford,
- Murray Grossman,
- Matthew GH Hall,
- Edward D. Huey,
- David Irwin,
- Maria I. Lapid,
- Irene Litvan,
- Ian R. Mackenzie,
- Joseph C. Masdeu,
- Mario F. Mendez,
- Naomi Nevler,
- Chiadi U. Onyike,
- Belen Pascual,
- Peter Pressman,
- Katherine P. Rankin,
- Buddhika Ratnasiri,
- Julio C. Rojas,
- Maria Carmela Tartaglia,
- Bonnie Wong,
- Maria Luisa Gorno‐Tempini,
- Bradley F. Boeve,
- Howard J. Rosen,
- Adam L. Boxer,
- Adam M. Staffaroni
Affiliations
- Jack Carson Taylor
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Hilary W. Heuer
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Annie L. Clark
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Amy B. Wise
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Masood Manoochehri
- Department of Neurology Columbia University New York New York USA
- Leah Forsberg
- Department of Neurology Mayo Clinic Rochester Minnesota USA
- Carly Mester
- Department of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA
- Meghana Rao
- Department of Neurology Mayo Clinic Rochester Minnesota USA
- Daniell Brushaber
- Department of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA
- Joel Kramer
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Ariane E. Welch
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- John Kornak
- Department of Epidemiology and Biostatistics University of California San Francisco California USA
- Walter Kremers
- Department of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA
- Brian Appleby
- Department of Neurology Case Western Reserve University Cleveland Ohio USA
- Bradford C. Dickerson
- Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA
- Kimiko Domoto‐Reilly
- Department of Neurology University of Washington Seattle Washington USA
- Julie A. Fields
- Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA
- Nupur Ghoshal
- Center for Advanced Medicine Memory Diagnostic Center Washington University Saint Louis Missouri USA
- Neill Graff‐Radford
- Department of Neuroscience Mayo Clinic Jacksonville Florida USA
- Murray Grossman
- Department of Neurology University of Pennsylvania Philadelphia Pennsylvania USA
- Matthew GH Hall
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Edward D. Huey
- Department of Neurology Columbia University New York New York USA
- David Irwin
- Department of Neurology University of Pennsylvania Philadelphia Pennsylvania USA
- Maria I. Lapid
- Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA
- Irene Litvan
- Department of Neurosciences University of California San Diego California USA
- Ian R. Mackenzie
- Department of Pathology University of British Columbia Vancouver British Columbia Canada
- Joseph C. Masdeu
- Department of Neurology Houston Methodist Houston Texas USA
- Mario F. Mendez
- Department of Neurology University of California Los Angeles California USA
- Naomi Nevler
- Department of Neurology University of Pennsylvania Philadelphia Pennsylvania USA
- Chiadi U. Onyike
- Department of Psychiatry and Behavioral Sciences Johns Hopkins University Baltimore Maryland USA
- Belen Pascual
- Department of Neurology Houston Methodist Houston Texas USA
- Peter Pressman
- Department of Neurology University of Colorado Aurora Colorado USA
- Katherine P. Rankin
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Buddhika Ratnasiri
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Julio C. Rojas
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Maria Carmela Tartaglia
- Tanz Centre for Research in Neurodegenerative Diseases, Division of Neurology University of Toronto Toronto Ontario Canada
- Bonnie Wong
- Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA
- Maria Luisa Gorno‐Tempini
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Bradley F. Boeve
- Department of Neurology Mayo Clinic Rochester Minnesota USA
- Howard J. Rosen
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Adam L. Boxer
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- Adam M. Staffaroni
- Department of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA
- DOI
- https://doi.org/10.1002/dad2.12423
- Journal volume & issue
-
Vol. 15,
no. 2
pp. n/a – n/a
Abstract
Abstract Introduction Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD‐mApp). Methods A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC‐FTLD = 0 [N = 101]; prodromal: 0.5 [N = 49]; symptomatic ≥1 [N = 51]; not measured [N = 13]) were asked to complete ALLFTD‐mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. Results It was feasible for participants to complete the ALLFTD‐mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests. Discussion These findings suggest that the ALLFTD‐mApp study protocol is feasible and acceptable for remote FTD research. HIGHLIGHTS The ALLFTD Mobile App is a smartphone‐based platform for remote, self‐administered data collection. The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities. Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders. Remote digital data collection was well accepted by participants with a variety of diagnoses.
Keywords
- adherence
- digital technology
- smartphone
- cognition
- neuropsychology
- frontotemporal lobar degeneration (ftld)
