Total Antioxidant Levels in Patients with Spinal Herniation

Abstract

Objective: Inflammatory response has been acknowledged to be an important factor in the process of disc degeneration and may play an important role in generation of pain, among patients with spinal herniation. The aim of this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and their ratio, oxidative stress index (OSI) in patients with spinal herniations, and the relationship between these dependent variables and location of herniation, gender and age. Materials and Methods: 19 female (48,72%) and 20 male (51,28%) patients are included in the study. TAS and TOS levels are measured by commercially available kits in laboratory (Rel Assay Diagnostics, Turkey). OSI levels are calculated by their ratio. Results: Results show that mean TAS level is 1.518 ± 0.176, mean TOS level is 3.168 ± 0.956, and mean OSI level is 0.222 ± 0.078 with 95 % confidence interval. No correlations are found between age with the TAS, TOS and OSI levels. Conclusion: Post-operative patients with spinal herniation have normal oxidative statuses and the location of herniation and gender seems to have no effect on the TAS, TOS and OSI levels.

Keywords

• spinal herniasyon
• antioksidan
• serbest radikal
• oksidatif stres
• spinal herniation
• antioxidant
• free radical
• oxidative stress