Toxins (Oct 2022)

Acute and Subacute Toxicity Studies of <i>Erodium guttatum</i> Extracts by Oral Administration in Rodents

  • Kaoutar Benrahou,
  • Hanae Naceiri Mrabti,
  • Hamza M. Assaggaf,
  • Salma Mortada,
  • Najoua Salhi,
  • Lamiaa Rouas,
  • Rim El Bacha,
  • Abdellah Dami,
  • Azlarab Masrar,
  • Mohammed Merae Alshahrani,
  • Ahmed Abdullah Al Awadh,
  • Abdelhakim Bouyahya,
  • Khang Wen Goh,
  • Long Chiau Ming,
  • Yahia Cherrah,
  • My El Abbes Faouzi

DOI
https://doi.org/10.3390/toxins14110735
Journal volume & issue
Vol. 14, no. 11
p. 735

Abstract

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The present study aimed to evaluate the acute and subacute toxicity profiles of Erodium guttatum extracts in mice using the methods described in the guidelines of the OECD. In the acute toxicity study, the LD50 value was greater than 2000 mg/kg. The subacute toxicity study of E. guttatum extracts showed no significant changes in body or organ weights. The administration of E. guttatum extracts to mice at a dose of 200 mg/kg led to an increase in white blood cells, platelets and hemoglobin. Moreover, the aqueous extract of E. guttatum only decreased liver aspartate aminotransferase (ASAT) levels at a dose of 200 mg/kg, and creatinine and urea levels did not show any significant alterations compared to the control group. Our results showed that the extracts of E. guttatum caused a slight increase in alanine aminotransferase (ALAT) and triglycerides. The histological study showed that mice treated with E. guttatum extracts experienced some histopathological changes in the liver, particularly with the methanolic extract, and slight changes in the kidneys and pancreas. Regarding the renal profile, no toxicity was observed. These results provide basic information on the toxicological profile of E. guttatum used in traditional medicine.

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