Nature Communications (Dec 2021)
2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA
- Boris Pantic,
- Daniel Ives,
- Mara Mennuni,
- Diego Perez-Rodriguez,
- Uxoa Fernandez-Pelayo,
- Amaia Lopez de Arbina,
- Mikel Muñoz-Oreja,
- Marina Villar-Fernandez,
- Thanh-mai Julie Dang,
- Lodovica Vergani,
- Iain G. Johnston,
- Robert D. S. Pitceathly,
- Robert McFarland,
- Michael G. Hanna,
- Robert W. Taylor,
- Ian J. Holt,
- Antonella Spinazzola
Affiliations
- Boris Pantic
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Daniel Ives
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Mara Mennuni
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Diego Perez-Rodriguez
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Uxoa Fernandez-Pelayo
- Biodonostia Health Research Institute
- Amaia Lopez de Arbina
- Biodonostia Health Research Institute
- Mikel Muñoz-Oreja
- Biodonostia Health Research Institute
- Marina Villar-Fernandez
- Biodonostia Health Research Institute
- Thanh-mai Julie Dang
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Lodovica Vergani
- Department of Neurosciences, University of Padova
- Iain G. Johnston
- Faculty of Mathematics and Natural Sciences, University of Bergen
- Robert D. S. Pitceathly
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery
- Robert McFarland
- Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University
- Michael G. Hanna
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery
- Robert W. Taylor
- Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University
- Ian J. Holt
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- Antonella Spinazzola
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus
- DOI
- https://doi.org/10.1038/s41467-021-26829-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
It has been a longstanding goal to promote the propagation of functional mitochondrial DNAs at the expense of pathological molecules in cells where the two species coexist. Here, the authors show that restricting the availability of glucose and glutamine can achieve this outcome.
