Effects of Successful Parathyroidectomy on Clinical, Laboratory, and Cardiovascular Manifestations of Primary Hyperparathyroidism

Abstract

Objective: Primary hyperparathyroidism (PHPT) is a disease characterized by excessive parathyroid hormone (PTH) secretion from one or more of the 4 parathyroid glands. The disease affects many organ systems and causes a variety of symptoms. Surgical removal of abnormal parathyroid glands is the most effective treatment for the disease. In this study, we aimed to investigate the effects of parathyroidectomy on the clinical, laboratory, and cardiovascular manifestations of primary hyperparathyroidism. Methods: Thirty-five patients who underwent parathyroidectomy were included in the study. Biochemical, anthropometric, and bone densitometry results of the patients with PHPT before and after parathyroidectomy were retrieved from the patient's files. In addition, carotid intima–media thickness (CIMT) measured by ultrasonography and epicardial fat tissue (EAT) thickness values measured by transthoracic echocardiography were also included in the study. Results: A significant improvement was detected in serum calcium, phosphorus, and PTH levels and 24-hour urinary calcium levels in the postoperative period (P < .001). A significant decrease was found in CIMT values after parathyroidectomy compared to the preoperative period (P < .001). No significant change was detected in EAT thickness after parathyroidectomy (P=.798). There was no correlation between EAT thickness and CIMT values measured in the postoperative period and other laboratory and clinical parameters. Conclusion: It was determined that the CIMT level decreased significantly after parathyroidectomy. No parameter was found to correlate with the CIMT measured in the postoperative period.