Department of Biomedicine, Aarhus University, Aarhus, Denmark; PROMEMO, The Center for Proteins in Memory, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark
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Department of Biomedicine, Aarhus University, Aarhus, Denmark; PROMEMO, The Center for Proteins in Memory, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark
Solbjørg Østergaard Feld-Jakobsen
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Bernadett Mercedesz Molnar
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Mads Zippor Kirkegaard
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Maria Moltesen
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Aleksandra Okrasa
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Jelena Radulovic
Department of Biomedicine, Aarhus University, Aarhus, Denmark; PROMEMO, The Center for Proteins in Memory, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, United States; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York, United States
Department of Biomedicine, Aarhus University, Aarhus, Denmark; PROMEMO, The Center for Proteins in Memory, Aarhus University, Aarhus, Denmark; DANDRITE, The Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark
The claustrum complex is viewed as fundamental for higher-order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some of the key roles of the CLA complex can be attributed to the connectivity and function of a small group of neurons in its ventral subregion, the endopiriform (EN). We identified a subpopulation of EN neurons by their projection to the ventral CA1 (ENvCA1-proj. neurons), embedded in recurrent circuits with other EN neurons and the piriform cortex. Although the ENvCA1-proj. neuron activity was biased toward novelty across stimulus categories, their chemogenetic inhibition selectively disrupted the memory-guided but not innate responses of mice to novelty. Based on our functional connectivity analysis, we suggest that ENvCA1-proj. neurons serve as an essential node for recognition memory through recurrent circuits mediating sustained attention to novelty, and through feed-forward inhibition of distal vCA1 neurons shifting memory-guided behavior from familiarity to novelty.
