Frontiers in Cellular and Infection Microbiology (Jul 2020)

The Role of Non-coding RNAs in Viral Myocarditis

  • Cong Zhang,
  • Cong Zhang,
  • Cong Zhang,
  • Yan Xiong,
  • Lijin Zeng,
  • Lijin Zeng,
  • Lijin Zeng,
  • Zhihua Peng,
  • Zhihua Peng,
  • Zhihua Peng,
  • Zhihao Liu,
  • Hong Zhan,
  • Zhen Yang,
  • Zhen Yang,
  • Zhen Yang

DOI
https://doi.org/10.3389/fcimb.2020.00312
Journal volume & issue
Vol. 10

Abstract

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Viral myocarditis (VMC) is a disease characterized as myocardial parenchyma or interstitium inflammation caused by virus infection, especially Coxsackievirus B3 (CVB3) infection, which has no accurate non-invasive examination for diagnosis and specific drugs for treatment. The mechanism of CVB3-induced VMC may be related to direct myocardial damage of virus infection and extensive damage of abnormal immune response after infection. Non-coding RNA (ncRNA) refers to RNA that is not translated into protein and plays a vital role in many biological processes. There is expanding evidence to reveal that ncRNAs regulate the occurrence and development of VMC, which may provide new treatment or diagnosis targets. In this review, we mainly demonstrate an overview of the potential role of ncRNAs in the pathogenesis, diagnosis and treatment of CVB3-induced VMC.

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