Pathogenetic role of proteinase-inhibitor system in the development of local and systemic pathology

Abstract

The experimental and clinical research of nonspecific proteinase-inhibitor system components role in pathogenesis of inflammation and ischemia-reperfusion syndrome on the level of organism and on organ level was conducted. Common mechanisms of changes of proteinases and their inhibitors levels are revealed. On the basis of these results the place of systemic inflammatory response syndrome in pathogenesis of urgent clinical states is grounded. Classification of shocks on the basis of integration of concepts of shock and systemic inflammatory response syndrome is proposed. According to this classification it is suggested to divide shocks into 2 groups with primary and secondary systemic inflammatory response syndrome formation.

Keywords

• shock
• inflammation
• systemic inflammatory response syndrome
• proteinases
• classification