Nature Communications (Jun 2021)

3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia

  • Lu Yang,
  • Fengling Chen,
  • Haichuan Zhu,
  • Yang Chen,
  • Bingjie Dong,
  • Minglei Shi,
  • Weitao Wang,
  • Qian Jiang,
  • Leping Zhang,
  • Xiaojun Huang,
  • Michael Q. Zhang,
  • Hong Wu

DOI
https://doi.org/10.1038/s41467-021-24044-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.