Biological Evaluation of a Mitochondrial Phosphoenolpyruvate Carboxykinase Inhibitor
Sergio Rodríguez-Arévalo,
Sònia Abás,
Marc Aragó,
Juan Moreno-Felici,
Petra Hyroššová,
Jose Carlos Perales,
Carles Galdeano,
Tiziana Ginex,
Francisco Javier Luque,
Carmen Escolano
Affiliations
Sergio Rodríguez-Arévalo
Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain
Sònia Abás
Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain
Marc Aragó
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Juan Moreno-Felici
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Petra Hyroššová
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Jose Carlos Perales
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Carles Galdeano
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona 08028, Spain
Tiziana Ginex
Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08921, Spain
Francisco Javier Luque
Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08921, Spain
Carmen Escolano
Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain
Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzingthe decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
