Communications Biology (Sep 2022)
Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
- Catherine R. Dufour,
- Hui Xia,
- Wafa B’chir,
- Marie-Claude Perry,
- Uros Kuzmanov,
- Anastasiia Gainullina,
- Kurt Dejgaard,
- Charlotte Scholtes,
- Carlo Ouellet,
- Dongmei Zuo,
- Virginie Sanguin-Gendreau,
- Christina Guluzian,
- Harvey W. Smith,
- William J. Muller,
- Etienne Audet-Walsh,
- Alexey A. Sergushichev,
- Andrew Emili,
- Vincent Giguère
Affiliations
- Catherine R. Dufour
- Goodman Cancer Institute, McGill University
- Hui Xia
- Goodman Cancer Institute, McGill University
- Wafa B’chir
- Goodman Cancer Institute, McGill University
- Marie-Claude Perry
- Goodman Cancer Institute, McGill University
- Uros Kuzmanov
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Anastasiia Gainullina
- ITMO University, 49 Kronverksky Prospekt
- Kurt Dejgaard
- Department of Biochemistry, Faculty of Medicine, McGill University
- Charlotte Scholtes
- Goodman Cancer Institute, McGill University
- Carlo Ouellet
- Goodman Cancer Institute, McGill University
- Dongmei Zuo
- Goodman Cancer Institute, McGill University
- Virginie Sanguin-Gendreau
- Goodman Cancer Institute, McGill University
- Christina Guluzian
- Goodman Cancer Institute, McGill University
- Harvey W. Smith
- Goodman Cancer Institute, McGill University
- William J. Muller
- Goodman Cancer Institute, McGill University
- Etienne Audet-Walsh
- Goodman Cancer Institute, McGill University
- Alexey A. Sergushichev
- ITMO University, 49 Kronverksky Prospekt
- Andrew Emili
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Vincent Giguère
- Goodman Cancer Institute, McGill University
- DOI
- https://doi.org/10.1038/s42003-022-03942-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
Murine hearts deficient in ErbB2 and/or ERRα are used to profile the adverse cardiac remodeling associated with potential targeted breast cancer treatments by phosphoproteomic, transcriptomic and metabolomic profiling.
