Hypoxia related long non-coding RNAs in ischemic stroke

Jiawei Yao; Yiming Du; Junsi Liu; Ilgiz Gareev; Guang Yang; Xiaohui Kang; Xiaoxiong Wang; Ozal Beylerli; Xin Chen

Non-coding RNA Research (Dec 2021)

Hypoxia related long non-coding RNAs in ischemic stroke

Jiawei Yao,
Yiming Du,
Junsi Liu,
Ilgiz Gareev,
Guang Yang,
Xiaohui Kang,
Xiaoxiong Wang,
Ozal Beylerli,
Xin Chen

Affiliations

Jiawei Yao: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China
Yiming Du: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China
Junsi Liu: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China
Ilgiz Gareev: Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia
Guang Yang: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China
Xiaohui Kang: Department of Pharmacy, Rizhao People's Hospital, Rizhao, 276826, Shandong Province, China
Xiaoxiong Wang: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Corresponding author. Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Ozal Beylerli: Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia; Corresponding author.
Xin Chen: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Corresponding author. Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.

Journal volume & issue: Vol. 6, no. 4
pp. 153 – 158

Abstract

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With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA) playing an important regulatory role throughout ischemic stroke. Hypoxia, generated from reduction or interruption of cerebral blood flow, leads to changes in lncRNA expression, which then influence disease progression. Therefore, we reviewed studies on expression of hypoxia-related lncRNAs and relevant molecular mechanism in ischemic stroke. Considering that hypoxia-inducible factor (HIF) is a crucial regulator in hypoxic progress, we mainly focus on the HIF-related lncRNA which regulates the expression of HIF or is regulated by HIF, further reveal their pathogenesis and adaption after brain ischemia and hypoxia, so as to find effective biomarker and therapeutic targets.

Published in Non-coding RNA Research

ISSN: 2468-0540 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/non-coding-rna-research/

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