Communications Biology (Feb 2021)

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes

  • Alena Ivashenka,
  • Christian Wunder,
  • Valerie Chambon,
  • Roger Sandhoff,
  • Richard Jennemann,
  • Estelle Dransart,
  • Katrina Podsypanina,
  • Bérangère Lombard,
  • Damarys Loew,
  • Christophe Lamaze,
  • Francoise Poirier,
  • Hermann-Josef Gröne,
  • Ludger Johannes,
  • Massiullah Shafaq-Zadah

DOI
https://doi.org/10.1038/s42003-021-01693-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal barrier relies on this glycolipid and lectin (GL-Lect)-mediated endocytosis.