Nature Communications (Jan 2021)
Characterization of a new Leishmania major strain for use in a controlled human infection model
- Helen Ashwin,
- Jovana Sadlova,
- Barbora Vojtkova,
- Tomas Becvar,
- Patrick Lypaczewski,
- Eli Schwartz,
- Elizabeth Greensted,
- Katrien Van Bocxlaer,
- Marion Pasin,
- Kai S. Lipinski,
- Vivak Parkash,
- Greg Matlashewski,
- Alison M. Layton,
- Charles J. Lacey,
- Charles L. Jaffe,
- Petr Volf,
- Paul M. Kaye
Affiliations
- Helen Ashwin
- York Biomedical Research Institute, Hull York Medical School, University of York
- Jovana Sadlova
- Department of Parasitology, Faculty of Science, Charles University
- Barbora Vojtkova
- Department of Parasitology, Faculty of Science, Charles University
- Tomas Becvar
- Department of Parasitology, Faculty of Science, Charles University
- Patrick Lypaczewski
- Department of Microbiology and Immunology, McGill University
- Eli Schwartz
- The Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University
- Elizabeth Greensted
- York Biomedical Research Institute, Hull York Medical School, University of York
- Katrien Van Bocxlaer
- York Biomedical Research Institute, Hull York Medical School, University of York
- Marion Pasin
- Vibalogics GmbH
- Kai S. Lipinski
- Vibalogics GmbH
- Vivak Parkash
- York Biomedical Research Institute, Hull York Medical School, University of York
- Greg Matlashewski
- Department of Microbiology and Immunology, McGill University
- Alison M. Layton
- York Biomedical Research Institute, Hull York Medical School, University of York
- Charles J. Lacey
- York Biomedical Research Institute, Hull York Medical School, University of York
- Charles L. Jaffe
- The Hebrew University-Hadassah Medical School
- Petr Volf
- Department of Parasitology, Faculty of Science, Charles University
- Paul M. Kaye
- York Biomedical Research Institute, Hull York Medical School, University of York
- DOI
- https://doi.org/10.1038/s41467-020-20569-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM studies of sand fly transmitted cutaneous leishmaniasis.
