Nature Communications (Oct 2018)

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

  • Andreas H. Laustsen,
  • Aneesh Karatt-Vellatt,
  • Edward W. Masters,
  • Ana Silvia Arias,
  • Urska Pus,
  • Cecilie Knudsen,
  • Saioa Oscoz,
  • Peter Slavny,
  • Daniel T. Griffiths,
  • Alice M. Luther,
  • Rachael A. Leah,
  • Majken Lindholm,
  • Bruno Lomonte,
  • José María Gutiérrez,
  • John McCafferty

DOI
https://doi.org/10.1038/s41467-018-06086-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neutralizing dendrotoxin-mediated neurotoxicity using venom challenge in vivo models.