The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation

Abstract

The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca2+ store because different Ca2+ regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca2+-ATPase and secretory pathway Ca2+-ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca2+ release and uptake in the GA have now been established. Here, based on careful backward looking on compartments and patterns in GA Ca2+ regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca2+ adjustment model, in which GA acts as part of the panel point.

Keywords

• Ca2+ regulators
• Cytosolic calcium
• Golgi apparatus
• Intracellular calcium store