Reading related white matter structures in adolescents are influenced more by dysregulation of emotion than behavior

Tzipi Horowitz-Kraus; Scott K. Holland; Amelia L. Versace; Michele A. Bertocci; Genna Bebko; Jorge R.C. Almeida; Susan B. Perlman; Michael J. Travis; Mary Kay Gill; Lisa Bonar; Claudiu Schirda; Jeffrey L. Sunshine; Boris Birmaher; Gerry Taylor; Vaibhav A. Diwadkar; Sarah M. Horwitz; David Axelson; Thomas Frazier; Eugene L. Arnold; Mary A. Fristad; Eric A. Youngstrom; Robert L. Findling; Mary L. Phillips

NeuroImage: Clinical (Jan 2017)

Reading related white matter structures in adolescents are influenced more by dysregulation of emotion than behavior

Tzipi Horowitz-Kraus,
Scott K. Holland,
Amelia L. Versace,
Michele A. Bertocci,
Genna Bebko,
Jorge R.C. Almeida,
Susan B. Perlman,
Michael J. Travis,
Mary Kay Gill,
Lisa Bonar,
Claudiu Schirda,
Jeffrey L. Sunshine,
Boris Birmaher,
Gerry Taylor,
Vaibhav A. Diwadkar,
Sarah M. Horwitz,
David Axelson,
Thomas Frazier,
Eugene L. Arnold,
Mary A. Fristad,
Eric A. Youngstrom,
Robert L. Findling,
Mary L. Phillips

Affiliations

Tzipi Horowitz-Kraus: Cincinnati Children's Hospital Medical Center, University of Cincinnati, United States; Educational Neuroimaging Center, Faculty of Education in Science and Technology, Technion, Haifa, Israel; Corresponding author at: Cincinnati Children's Research Foundation, Pediatric Neuroimaging Research Consortium, 3333 Burnet Ave, Cincinnati, OH 45229-3039, United States.
Scott K. Holland: Cincinnati Children's Hospital Medical Center, University of Cincinnati, United States
Amelia L. Versace: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Michele A. Bertocci: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Genna Bebko: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Jorge R.C. Almeida: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Susan B. Perlman: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Michael J. Travis: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Mary Kay Gill: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Lisa Bonar: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Claudiu Schirda: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Jeffrey L. Sunshine: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Boris Birmaher: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States
Gerry Taylor: University Hospitals Case Medical Center, Case Western Reserve University, United States
Vaibhav A. Diwadkar: Department of Psychiatry and Behavioral Neuroscience, Wayne State University, United States
Sarah M. Horwitz: Department of Child Psychiatry, New York University School of Medicine, United States
David Axelson: Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States
Thomas Frazier: Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States
Eugene L. Arnold: Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States
Mary A. Fristad: Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States
Eric A. Youngstrom: Department of Psychology, University of North Carolina at Chapel Hill, United States
Robert L. Findling: University Hospitals Case Medical Center, Case Western Reserve University, United States; Department of Psychiatry, Johns Hopkins University, United States
Mary L. Phillips: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States

Journal volume & issue: Vol. 15
pp. 732 – 740

Abstract

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Mood disorders and behavioral are broad psychiatric diagnostic categories that have different symptoms and neurobiological mechanisms, but share some neurocognitive similarities, one of which is an elevated risk for reading deficit. Our aim was to determine the influence of mood versus behavioral dysregulation on reading ability and neural correlates supporting these skills in youth, using diffusion tensor imaging in 11- to 17-year-old children and youths with mood disorders or behavioral disorders and age-matched healthy controls. The three groups differed only in phonological processing and passage comprehension. Youth with mood disorders scored higher on the phonological test but had lower comprehension scores than children with behavioral disorders and controls; control participants scored the highest. Correlations between fractional anisotropy and phonological processing in the left Arcuate Fasciculus showed a significant difference between groups and were strongest in behavioral disorders, intermediate in mood disorders, and lowest in controls. Correlations between these measures in the left Inferior Longitudinal Fasciculus were significantly greater than in controls for mood but not for behavioral disorders. Youth with mood disorders share a deficit in the executive-limbic pathway (Arcuate Fasciculus) with behavioral-disordered youth, suggesting reduced capacity for engaging frontal regions for phonological processing or passage comprehension tasks and increased reliance on the ventral tract (e.g., the Inferior Longitudinal Fasciculus). The low passage comprehension scores in mood disorder may result from engaging the left hemisphere. Neural pathways for reading differ mainly in executive-limbic circuitry. This new insight may aid clinicians in providing appropriate intervention for each disorder. Keywords: Mood disorders, Behavioral disorders, Reading, White matter tracts, Phonological processing, Passage comprehension

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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