The Voltammetric Determination of Epinephrine on an Au Electrode Modified with Electropolymerized 3,5-Diamino-1,2,4-Triazole Film

Abstract

A gold electrode (Au) was modified with 3,5-diamino-1,2,4-triazole (35DT). The electrochemical behavior of epinephrine (EP) was evaluated on the modified electrode (35DT-Au) by the differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques. For the oxidation of EP, the 35DT-Au modified electrode surface showed an good electrocatalytic activity. The modified electrode was used to determine EP by using DPV technique. Under the optimum conditions, the calibration curve for EP was obtained in the ranges of 0.9 to 32.31 μM and 32.31 to 1050 μM and the detection limits (LOD) was found as 0.39 and 12.33 μM, respectively. For the oxidation process of EP, the 35DT-Au modified electrode exhibited a good repeatability, reproducibility, stability and sensitivity. Finally, the determination of EP in commercial injectable adrenaline samples were successfully applied.

Keywords

• epinephrine
• coating
• electrochemical behaviour
• voltammetric determination
• drug