Nature Communications (Jan 2020)
A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
Abstract
Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in response to injury.