Nature Communications (Jan 2020)

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

  • Yuki Matsushita,
  • Mizuki Nagata,
  • Kenneth M. Kozloff,
  • Joshua D. Welch,
  • Koji Mizuhashi,
  • Nicha Tokavanich,
  • Shawn A. Hallett,
  • Daniel C. Link,
  • Takashi Nagasawa,
  • Wanida Ono,
  • Noriaki Ono

DOI
https://doi.org/10.1038/s41467-019-14029-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in response to injury.