Comparison of ondansetron, metoclopramid, hyoscine and dexamethasone for prevention of post-operative vomiting in cataract surgery

Abstract

Introduction: Postoperative nausea and vomiting (PONV) complicates the lives of patients. Most of antiemetic drugs used prevent PONV after surgery, but they have undesirable adverse effects such as excessive sedation, hypotension, dysphoria and extrapyramidal symptoms. This study aimed to find out the best drugs for the above-mentioned problem. Materials and Methods: In a prospective double blinded trial, 250 patients with ASA class I, II undergoing general anesthesia for cataract surgery were assigned randomly in five groups. Before the induction of anesthesia, the patients received Metoclopramide, Dexamethasone, Hyoscine, or Ondansetron and plasibo randomly. Vomiting episodes were recorded during 24 hours after the surgery. Results: The incidence of vomiting was 10% for Dexamethasone, 8% for Metoclopramide, 6% for Ondansetron, 12.3% for Hyoscine, and 27.2% for plasibo groups. Conclusion: The incidence of vomiting after cataract surgery showed a significant difference among the five drugs. Ondansetron was the most effective drug for prevention of post-operative vomiting. Of course, other drugs can be used in this operation as well.

Keywords

• ondansetron
• dexamethasone
• metoclopramide
• hyoscine
• scopolamine
• placebos