Nature Communications (Dec 2022)
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
- Allison K. Maher,
- Katie L. Burnham,
- Emma M. Jones,
- Michelle M. H. Tan,
- Rocel C. Saputil,
- Laury Baillon,
- Claudia Selck,
- Nicolas Giang,
- Rafael Argüello,
- Clio Pillay,
- Emma Thorley,
- Charlotte-Eve Short,
- Rachael Quinlan,
- Wendy S. Barclay,
- Nichola Cooper,
- Graham P. Taylor,
- Emma E. Davenport,
- Margarita Dominguez-Villar
Affiliations
- Allison K. Maher
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Katie L. Burnham
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Emma M. Jones
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Michelle M. H. Tan
- Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London
- Rocel C. Saputil
- Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London
- Laury Baillon
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Claudia Selck
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Nicolas Giang
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Rafael Argüello
- Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy
- Clio Pillay
- Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London
- Emma Thorley
- Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London
- Charlotte-Eve Short
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Rachael Quinlan
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Wendy S. Barclay
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Nichola Cooper
- Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London
- Graham P. Taylor
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- Emma E. Davenport
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Margarita Dominguez-Villar
- Department of Infectious Diseases, Faculty of Medicine, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-35638-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response and a pro-thrombotic signature following secondary SARS-CoV-2 challenge.
