Nature Communications (May 2018)
Male germ cells support long-term propagation of Zika virus
- Christopher L. Robinson,
- Angie C. N. Chong,
- Alison W. Ashbrook,
- Ginnie Jeng,
- Julia Jin,
- Haiqi Chen,
- Elizabeth I. Tang,
- Laura A. Martin,
- Rosa S. Kim,
- Reyn M. Kenyon,
- Eileen Do,
- Joseph M. Luna,
- Mohsan Saeed,
- Lori Zeltser,
- Harold Ralph,
- Vanessa L. Dudley,
- Marc Goldstein,
- Charles M. Rice,
- C. Yan Cheng,
- Marco Seandel,
- Shuibing Chen
Affiliations
- Christopher L. Robinson
- Department of Surgery, Weill Cornell Medical College
- Angie C. N. Chong
- Department of Surgery, Weill Cornell Medical College
- Alison W. Ashbrook
- Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University
- Ginnie Jeng
- Department of Surgery, Weill Cornell Medical College
- Julia Jin
- Department of Surgery, Weill Cornell Medical College
- Haiqi Chen
- The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council
- Elizabeth I. Tang
- The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council
- Laura A. Martin
- Department of Surgery, Weill Cornell Medical College
- Rosa S. Kim
- Penn State College of Medicine
- Reyn M. Kenyon
- Department of Surgery, Weill Cornell Medical College
- Eileen Do
- Department of Surgery, Weill Cornell Medical College
- Joseph M. Luna
- Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University
- Mohsan Saeed
- Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University
- Lori Zeltser
- Naomi Berrie Diabetes Center, Columbia University
- Harold Ralph
- Weill Cornell Medical College-Microscopy and Image Analysis Core Facility
- Vanessa L. Dudley
- Institute of Reproductive Medicine at Weill Cornell Medicine, Weill Cornell Medicine–New York Presbyterian Hospital
- Marc Goldstein
- Department of Urology and Institute for Reproductive Medicine, Weill Cornell Medical College of Cornell University
- Charles M. Rice
- Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University
- C. Yan Cheng
- The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council
- Marco Seandel
- Department of Surgery, Weill Cornell Medical College
- Shuibing Chen
- Department of Surgery, Weill Cornell Medical College
- DOI
- https://doi.org/10.1038/s41467-018-04444-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l.
